The calciferol receptor (VDR) is a necessary protein that is turned on by calciferol. It is associated with maintaining the mineral equilibrium in the body and contributing to growth and hair production. It also interacts with adipose muscle.
VDRs happen to be expressed inside the parathyroid glands, intestines, epithelial virtual data room comparison cells, and many immune system cell types. They are considered to regulate the intestinal compression of calcium supplement, and to mediate some of the effects of vitamin D upon bone routine service. Fortunately they are thought to play an important part in metabolic process.
VDR is found in a variety of flesh, including epithelial cells, macrophages, neutrophils, and skin keratinocytes. However , they are really most widely depicted in the kidneys and osseins.
The VDR is phosphorylated about serine residues by a number of protein kinases. These kinases include PKA and PKC. The effect of them kinases on VDR is normally ligand depending on. Specifically, the phosphorylation of Ser51 by PKC reduced VDR nuclear localization. Likewise, phosphorylation of Ser182 by PKA reduced RXR heterodimerization.
Research have shown that VDRs can be found in a part of glial cells, particularly in oligodendrocytes in white subject. Although VDR immunoreactivity has been found in a number of glial cell lines, no proof has been shown that the presence of VDR in glia is a cause for increased likelihood of tumorigenesis.
Additionally , VDR seems present in a subset of neurons. Actually nuclear discoloration has been revealed in man cortex and glial cell-lines.
A large 220-kDa protein can be found in human key glioblastoma cellular material. In contrast, a little recombinant VDR-like protein was produced.